Botulinum
Toxin Injections (BOTOX ®)
Botulinum toxin injections (BTX), often referred
to by the product names BOTOX® Cosmetic or Myobloc®, are
biological toxins (botulinum toxin) transformed into a therapeutic
agent. Work with BTX began in the late 1960s to treat neurological
disorders. Today, BTX is used for the treatment of frown lines,
forehead furrows, "crow's feet," lines and wrinkles of the lower
face, and even nasal muscles (to decrease nostril flaring). BTX
injections have proven to be a very popular nonsurgical cosmetic
procedure; see current American Society for Aesthetic Plastic
Surgery (ASAPS) statistics. Aesthetic plastic surgeons have found
that the type of lines and wrinkles that respond to BTX injections
are those caused by the muscles-specifically those muscles that
contract during facial expressions such as frowning or squinting.
Technique:
The patient is asked to contract the muscles in
the area being treated so the surgeon can determine the proper
location for injection. In most cases, BTX is injected directly
into the muscle with a tiny needle. It takes a few days to realize
the effect of BTX injections.
Benefits:
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No downtime. Patients can immediately resume normal activities.
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Long experience has proven BTX to be safe. To date, no
systemic complications associated with BTX injections have
been documented.
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Treatment is reversible within several months.
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May be beneficial for treatment of migraine headaches.
Other Considerations:
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BTX injections are a temporary solution for the treatment
of wrinkles. The effects last from 3-4 months and require
repeat treatments.
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Possible side effects include local numbness, swelling,
bruising, or a burning sensation during injection. Some
patients have reported temporary headache and nausea. Most
complications are of short duration and can be avoided with
proper injection techniques.
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A small percentage of patients are reported to experience
no improvement at all.
ASAPS Position:
The American Society for Aesthetic Plastic Surgery
(ASAPS) maintains that BTX injections for aesthetic purposes appear
to be safe and effective. Patients who show early signs of aging,
as well as those who may not be suitable candidates for more extensive
aesthetic facial surgery, may be good candidates for this procedure.
Certain medications (some antibiotics, anti-inflammatories, or
aspirin) and even some vitamins and herbs may increase the potency
of BTX and may increase bleeding and bruising at the time of injection.
Therefore, patients should be candid with their surgeon about
all medications and supplements. Pregnant or nursing women should
postpone undergoing this procedure. It is not known whether injection
of BTX has any effect on a fetus or whether it is found in breast
milk.
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Collagen
Injections
Collagen injections were approved by the FDA in
1981. They have proven to be a very popular nonsurgical cosmetic
procedure; see current American Society for Aesthetic Plastic
Surgery (ASAPS) statistics. Injectable Zyderm and Zyplast collagen,
natural substances derived from purified bovine (cow) collagen,
essentially replace the natural collagen that the skin loses over
time. Human collagen are also available. Collagen injections are
most useful in the treatment of frown lines, "crow's feet," and
nasolabial folds (smile lines). To improve deeper creases or enhance
lip fullness, there also are filler materials, such as soft ePTFE
(expanded polytetrafluoro-ethylene) that can be surgically implanted.
Technique:
Collagen, which contains local anesthesia, is injected
with a tiny needle into the skin depressions being treated. Several
injections may be needed, depending on the length and depth of
the wrinkle. The procedure for both injections and implants takes
less than an hour. Implantation procedures for the lips and nasolabial
areas are done with a local anesthetic. A tiny incision is placed
at either end of the site. Then the implant is inserted and positioned.
Incisions are closed with a suture.
Benefits:
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Safe, time-tested, effective treatment that provides immediate
results.
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No downtime for injectables-patients can immediately resume
work and all normal activities.
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No need to obtain tissue from another part of the body.
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Human collagen products do not require pre-testing
Other Considerations:
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Collagen is only temporarily effective. Repeat treatments
are needed every three to six months.
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There may be some slight bruising.
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Pretreatment testing for allergic reactions is recommended.
Allergic reactions can cause itching, redness, or other
symptoms.
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Fat
Injection
Body fat makes excellent soft tissue filler material.
Fat injection (also called autologous fat transplantation) transfers
fat from one part of the body to another to recontour the face;
diminish frown lines, crow's feet and nasolabial folds (smile
lines); and provide definition to areas like the cheeks and chin.
It can also be used to fill out depressed scarred areas on any
part of the body. Fat injection is not permanent, and may require
an effective maintenance program.
Technique:
The donor site (for example, abdomen, buttocks or
thighs) and the treatment site are injected with local anesthetic.
Intravenous (IV) fluids also are injected into the donor site
to facilitate fat collection. Fat cells are extracted through
a small needle attached to a syringe. The fat is then processed
to remove excess fluids and reinjected with another needle in
multiple thin strands in the desired area. "Overfilling" is a
necessary corrective due to fat absorption in the weeks after
treatment. Fat also can be harvested during a lipoplasty (liposuction)
procedure in one area of the body, and then reinjected in another.
For longest-lasting effect, patients generally receive 3 to 4
treatments over a six-month period.
Benefits:
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Natural, non-allergenic.
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Outpatient procedure that generally takes under an hour.
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Injections may last from several months to permanently.
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Little or no downtime.
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Minimal discomfort, which can be controlled with medication.
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Because fat is from the patient's own body, no pre-testing
is required and the fat cannot be rejected.
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Good alternative if the patient is allergic to bovine collagen.
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Cost effective if combined with another procedure like
lipoplasty (liposuction).
Other Considerations:
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Longevity of results can vary significantly from patient
to patient.
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Some swelling, bruising-usually about 48 hours. Patient
should avoid the sun until the condition subsides.
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Not every area is appropriate for fat injection. Injecting
fat into the breast, for example, makes cancer detection
via mammography more difficult and is strongly discouraged
(see ASAPS' Position Statement, "Fat Injection for Breast
Enlargement)."
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Lasts longest when reinjected in relatively stationary
areas (such as the cheeks).
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Hyaluronic
acid
Hyaluronic acid is a natural polysaccharide, that
in appropriate form, is a versatile soft tissue filler. Currently
available as the product name Restylane (also Restylane Fine Line
and Perlane) distributed by the Medicis company, and Hylaform
distributed by a company named Inamed. Hyaluronic acid is being
widely used for the management of wrinkles, fine lines, contour
deformities, and volumetric deficiencies of face, cheeks, and
lips associated with aging, developmental anomalies, and certain
diseases. Restylane/Hylaform does not represent the final answer
in the search for an ideal tissue filler but provides a predictable,
safe, user-friendly approach.
Technique:
Restylane/Hylaform is usually injected when the
patient is in the office, rather than requiring a hospital visit.
The areas of the skin to be treated are first coated with a topical
anesthetic, which is usually sufficient for the patient's comfort,
although a nerve block may be preferable for some patients. Hyaluronic
acid is a hydrophilic agent, which means that it attracts water
much like a sponge. This expansion contributes to the final volume
that is achieved. Therefore, underfilling is necessary, and many
patients will benefit from a touchup session in about three weeks
after the first treatment. Overfilling can lead to bumps and irregularities
which, although rare, can represent a small, temporary cosmetic
problem. For many, but certainly not all patients, the results
can last up to six months. It is especially effective for the
nasolabial folds, lip augmentation, and areas of contour deformities.
It is also an ideal adjunct for Botox treatment and is frequently
used in conjunction with Botox to correct lines and creases that
persist.
Benefits:
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A natural substance that does not require pretesting for
allergic reactions
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Injections can last for approximately six months
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Minimal discomfort
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Very few side effects
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Can apply makeup immediately and return to normal activities
Other Considerations:
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Bruising and swelling can occur
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Small bumps are infrequently visible or are palpable
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After about three weeks, repeat injections are often necessary
to achieve an ideal result